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Medical Science of Ukraine

Current

Vol. 22, No. 2, 2026

Medical Science of Ukraine

Medical Science of Ukraine

ISSN 2664-472X

EISSN 2664-4738 

Publisher: Bogomolets National Medical University



Retrieved from Vol. 21, No. 3, 2025

Homeokinetic classification of asthmatic syndrome taking into account the patient's vegetative passport and comorbidity form

https://doi.org/10.32345/2664-4738.3.2025.07

V. Sokrut, O. Lytvynova, O. Sokrut, A. Mullahmetov, M. Sokrut

Abstract

Background. Breathing practices are an important direction in rehabilitation and sports medicine, which can be defined as the science of optimizing impaired homeokinesis parameters and adaptation mechanisms. The form of asthmatic syndrome largely depends on the vegetative passport, the form of comorbidity and homeokinesis. Aim: to determine the forms of asthmatic syndrome taking into account the vegetative passport and the form of comorbidity. Materials and methods. The basic results were obtained by modern research methods at the Departments of Rehabilitation and Sports Medicine and Obstetrics and Gynecology of Donetsk National Medical University and the Medical Rehabilitation Center "Drive-Medical" (Kropivnitsky, Ukraine). Patients with asthmatic syndrome were divided into 2 groups according to the data of spectral analysis of heart rate (SASR) and automated determination of homeokinesis parameters and "vegetative passport". To determine the form of comorbidity, the level of calcium in the blood and hair was studied. Statistical processing of the obtained results was carried out using the program "Statistica-Stat-Soft" (USA). Results. The results of variational pulsometry, the power of heart rate spectra in the low (LF) and high (HF) frequency ranges, as well as their LF/HF ratio (sympathovagal balance index) confirmed the significant role of the vegetative passport in the pathogenesis of asthmatic syndrome. The index of sympatho-vagus balance in the control group was 1.60±0.05. Its value >1.65 indicated the dominance of sympathotonia, and <1.55 reflected vagotonia. The obtained patterns and the close correlation of the parameters of lung pathology with the vegetative passport confirmed the "vegetative-homeokinetic theory of pathology", which reflected the evolution of the concept of stress, the formation of maladaptation. Conclusion. The conducted studies allowed us to determine the informative indicators of the patient's vegetative passport, to formulate vagotonic and sympathotonic homeokinesis, the form of asthmatic syndrome and comorbidity

References

1. Sokrut MV, Gozhenko AI, Klymovitsky FV, Sokrut VM, Sokrut OP, Popov VM, Levitin EY, Lyakh YU. Violations of homeokinesis parameters in joint pathology and their endoprosthetics: scientific monograph. Lviv: Publishing House PP "Magnolia 2006", 2024 – 310 p. [Ukrainian]

2. Physical, rehabilitation medicine: Neurorehabilitation. Textbook for students and doctors / Edited by prof. V. Sokrut – Lviv: Publisher T. Marchenko. 2022;2. 292 p. [Ukrainian]

3. Sokrut MV. Elementosis in joint pathology and endoprosthetics: monograph. Slavyansk: Drukarskyi dvir, 2021. 218 p. [Ukrainian]

4. Mullakhmetov AG, Sokrut MV, Sokrut OP, Litvinova OV. Respiratory gymnastics for students depending on their vegetative passport. World of scientific research: materials of the XXXIII International scientific and practical Internet conference (Ternopil, June 24–25, 2025). – 2025. – Issue 43. – P. 66-76. Access mode: https://www.economy-confer.com.ua/full-article/6265/ [Ukrainian]

5. Hassan EEM, Abusaad FE, Mohammed BA. Effect of the Buteyko breathing technique on asthma severity control among school-age children. Egyptian Journal of Bronchology. 2022;16:149. DOI: https://doi.org/10.1186/ s43168-022-00149-3.

6. Liu A., Zhang Y., Yadav C. P., Chen W. An updated systematic review on asthma exacerbation risk prediction models between 2017 and 2023: risk of bias and applicability. Journal of Asthma and Allergy. 2025; 18:123–136. DOI: https://doi.org/10.2147/JAA.S509260.

7. Mai K, Maverakis E, Li J, Zhao M. Maintaining and Restoring Gradients of Ions in the Epidermis: The Role of Ion and Water Channels in Acute Cutaneous Wound Healing. Advances in Wound Care (New Rochelle). 2023;12(12):696–709. DOI: https://doi. org/10.1089/wound.2022.0128.

8. Du Y, Qi X, Zhang L, Yang Y, Chen T. Calcium influx–induced lytic cell death disrupts skin immune homeostasis. Cell Discovery. 2023:124. DOI: https://doi.org/10.1038/s41421-023- 00623-2.

9. Sokrut VM. Clinical test for determining the form of somatogenesis. [Internet]. Available on: https://sokrut.com/somatogenytest2. [Ukrainian]

10. McGregor J, Yates M, Thorley AJ. Asthma phenotypes in the era of personalized medicine. Journal of Clinical Medicine. 2023;12(19): 6207. DOI: https://doi.org/10.3390/jcm12196207.

11. Aztatzi-Aguilar OG, Vargas-Domínguez C, Debray-Garcia Y, et al. Biochemical and hematological relationship with the evaluation of autonomic dysfunction by heart rate recovery in patients with asthma and type 2 diabetes. Diagnostics. 2021;11(12): 2187. DOI: https://doi. org/10.3390/diagnostics11122187

12. Listyoko AS, Harada T, Inui G, Yamasaki A. Exploring the association between asthma and chronic comorbidities: impact on clinical outcomes. Frontiers in Medicine. 2024;11:1305638. DOI: https://doi.org/10.3389/ fmed.2024.1305638.

13. Habib N, Pasha MA, Tang DD. Current understanding of asthma pathogenesis and biomarkers. Cells. 2022;11(17): 2764. DOI: https://doi. org/10.3390/cells11172764.

14. Donoghue LJ, Benner C, Chang D, et al. Integrating biobank-scale genetics and plasma proteomics reveals evidence for causal processes in asthma risk and heterogeneity. Cell Genomics. 2025; 5(7):100840. DOI: https://doi. org/10.1016/j.xgen.2025.100840.

15. Kim J, Park M, Lee S Y. Update on inflammatory biomarkers for defining asthma phenotype. Allergy, Asthma & Immunology Research. 2024;16(5): 462–478. DOI: https://doi. org/10.4168/aair.2024.16.5.462.

16. Harfouch RM. Genetic, inflammatory and immunological biomarkers for the early assessment of allergic asthma: a current update. Polish Journal of Allergology. 2025; 2(1): 1-10. DOI: https://doi.org/10.5114/pja.2025.151298.

17. Sun B, Shen K, Zhao R, Li Y, Xiang M, Lin J. Precision medicine for severe asthma – biological targeted therapy. International Immunopharmacology. 2024;125:112189. DOI: https:// doi.org/10.1016/j.intimp.2024.112189.

18. Zhang Y, Li J, Wang X, Zhao J. Genetic biomarkers of sex differences in asthma prevalence determined by machine learning. Frontiers in Medicine. 2024;11:1397746. DOI: https://doi. org/10.3389/fmed.2024.1397746.

19. Zhu Y. Exploring biomarkers in asthma: insights from serum metabolomics. Allergy, Asthma & Immunology Research. 2024;16( 3): 211–225. DOI: https://doi. org/10.4168/aair.2024.16.3.211.

20. Ghusheyan MM, Al-Assemy A, Al-Nablus AI. Psychological stress and its association with bronchial asthma in adults in Saudi Arabia. Saudi Med. J. 2024; 46(5):560–567. DOI: https://doi.org/10.15537/smj.2024.5.10358074.

21. Salsman ML, Nordberg HO, Howell J, BerthetMiron MM, Rosenfield D, Ritz T. Psychological distress and symptom-related burnout in asthma during the COVID 19 pandemic. Journal of Behavioral Medicine. 2023;46(6):960–972. DOI: https://doi.org/10.1007/s10865-023- 00412-y.

22. Real FG, Svanes C, Macsali F, Omenaas ER. Hormonal factors and respiratory health in women – a review. Clinical Respiratory Journal. 2008;2(1):111-119. DOI: https://doi. org/10.1111/j.1752 699X.2008.00093.x.

23. Eun-Kyung Kon, Tae-Wook Kang, Taeyun Oh, Oak-Sung Choo, Young-Min Ye, Hae Sim Park, Ga-Young Ban. Nasal Transcriptome and Epigenome Analysis Identifies the Pathogenic Features of Aspirin Exacerbated Respiratory Disease. Allergy Asthma Immunol Res. 2023;15( 5): 682–694. DOI: https://doi. org/10.4168/aair.2023.15.5.682.

24. G-Y Ban, K Cho, S-H Kim, M K Yoon, J H Kim, H Y Lee, Y S Shin, Y-M Ye, J-Y Cho, H-S Park. Metabolomic analysis identifies potential diagnostic biomarkers for aspirin exacerbated respiratory disease. Clin Exp Allergy. 2017;47(1):37– 47. DOI: https://doi.org/10.1111/cea.12797.

25. McDuffie EL, Panettieri RA Jr, Scott CP. G₁₂/₁₃ signaling in asthma. Respiratory Research. 2024; 25:295. DOI: https://doi.org/10.1186/ s12931-024-02920-0.

26. Chiu KY, Li JG, Lin Y. Calcium channel blockers for lung function improvement in asthma: a systematic review and meta-analysis. Ann Allergy Asthma Immunol. 2017;119(6): 518– 523.e3. DOI: https://doi.org/10.1016/j. anai.2017.08.013.

27. Connett GJ. Asthma, classical conditioning, and the autonomic nervous system – a hypothesis for why children wheeze. Archives of Disease in Childhood. 2024 May;109(6):462– 467. DOI: https://doi.org/10.1136/archdischild-2023-325441.

28. Couto M, Silva D, Santos P, Queirós S, Delgado L, Moreira A. Exploratory study comparing dysautonomia between asthmatic and non asthmatic elite swimmers. Rev Port Pneumol. 2015;21(1):22–29. DOI: https://doi. org/10.1016/j.rppnen.2014.05.004. 

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Keywords:

asthma; vegetative nervous system, comorbidity

Pages 69-75

Suggested citation

Sokrut, V., Lytvynova, O., Sokrut, O., Mullahmetov, A., & Sokrut, M. (2025). Homeokinetic classification of asthmatic syndrome taking into account the patient's vegetative passport and comorbidity form. Medical Science of Ukraine, 21(3), 69-75. https://doi.org/10.32345/2664-4738.3.2025.07

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ISSN 2664-472X; e-ISSN 2664-4738

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