Abstract

Background. Typical clinical syndromes of organ failure (TCSOF) are a manifestation of dysadaptation during menopause in women. Their form largely depends on the vegetative passport, comorbidity and homeokinesis parameters. Aim: to determine the forms of TCSOF taking into account the vegetative passport, comorbidity and violations of homeokinesis parameters in women in menopause. Materials and methods. The basic results were obtained by modern research methods at the Departments of Rehabilitation and Sports Medicine and Obstetrics and Gynecology of Donetsk National Medical University and the Medical Rehabilitation Center "Drive-Medical" (Kropivnitsky, Ukraine). Patients with TCSOF were divided into 2 groups according to the data of spectral analysis of heart rate (SAHR) and automated determination of homeokinesis parameters and "vegetative passport". The form of comorbidity was determined by the level of calcium in the hair using the atomic absorption spectrometer "SolAAr-Mk2-MOZe" with an electrographite atomizer (Great Britain). Statistical processing of the obtained results was carried out using the program "Statistica-Stat-Soft" (USA). Results. The results of variational pulsometry, the power of the heart rate spectra in the low (LF) and high (HF) frequency ranges, as well as their LF/HF ratio (sympathovagal balance index) confirmed the significant role of the vegetative status in the pathogenesis of TCSOF. The sympathovagal balance index in the control group was 1.60±0.05. Its value >1.65 indicated the dominance of sympathotonia, and <1.55 reflected vagotonia. The form of comorbidity (calcium-deficient or calciumexcessive) was established by the content of intracellular calcium in the hair, which clarifies the "vegetative passport", correlates with the sympathovagal balance index, and shows the vectorial nature of the violation of homeokinesis parameters. The obtained patterns and the close correlation of the forms of TCSOF with the vegetative passport and comorbidity confirmed the "vegetative-homeokinetic theory of pathology", which reflected the evolution of the concept of stress, the formation of maladaptation. Conclusion. The study allowed us to determine the informative indicators of the patient's vegetative passport, to formulate vagotonic and sympathotonic homeokinesis, the form of TCSOF and comorbidity